We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is pre- dicted to encode a membrane-bound ligand, character- ized by an extracellular region containing several EGF- like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective ex- pression pattern of Dll4 within the vascular endotheli- um. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology.
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