DNA block copolymer micelles - A combinatorial tool for cancer nanotechnology

  • Alemdaroglu F
  • Alemdaroglu N
  • Langguth P
 et al. 
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Abstract

A novel micelle platform consisting of amphiphilic DNA block copolymers is introduced for chemotherapeutic drug delivery, allowing combinatorial testing of the drug carrier system. Oligodeoxy-nucleotide modified targeting units are "clicked" into the micelle corona by hybridization, allowing perfect control of surface functionalities of the nano-particle system. Cancer cells are efficiently killed when targeting units and chemotherapeutic act together within the DNA block copolymer aggregates.

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Authors

  • Fikri E. Alemdaroglu

  • N. Ceren Alemdaroglu

  • Peter Langguth

  • Andreas Herrmann

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