DNA logic gates

  • Okamoto A
  • Tanaka K
  • Saito I
  • 76

    Readers

    Mendeley users who have this article in their library.
  • 155

    Citations

    Citations of this article.

Abstract

A conceptually new logic gate based on DNA has been devised. Methoxybenzodeazaadenine (MDA), an artificial nucleobase which we recently developed for efficient hole transport through DNA, formed stable base pairs with T and C. However, a reasonable hole-transport efficiency was observed in the reaction for the duplex containing an MDA/T base pair, whereas the hole transport was strongly suppressed in the reaction using a duplex where the base opposite MDA was replaced by C. The influence of complementary pyrimidines on the efficiency of hole transport through MDA was quite contrary to the selectivity observed for hole transport through G. The orthogonality of the modulation of these hole-transport properties by complementary pyrimidine bases is promising for the design of a new molecular logic gate. The logic gate system was executed by hole transport through short DNA duplexes, which consisted of the “logic gate strand”, containing hole-transporting nucleobases, and the “input strand”, containing pyrimid...

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Akimitsu Okamoto

  • Kazuo Tanaka

  • Isao Saito

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free