DNA micelle flares for intracellular mrna imaging and gene therapy

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Abstract

Lighting the way with DNA: Molecular beacon micelle flares (MBMFs), based on self-assembly of diacyllipid-molecular-beacon conjugates (L-MBs; see figure), have been developed for combined mRNA detection and gene therapy. These MBMFs were shown to inhibit a model gene in vitro and decrease the viability of cancer cells in culture. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Chen, T., Wu, C. S., Jimenez, E., Zhu, Z., Dajac, J. G., You, M., … Tan, W. (2013). DNA micelle flares for intracellular mrna imaging and gene therapy. Angewandte Chemie - International Edition, 52(7), 2012–2016. https://doi.org/10.1002/anie.201209440

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