A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men

  • J. N
  • J.N. P
  • A. B
  • 2

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Aim: To determine the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Subjects and methods: A double-blind randomized controlled trial was conducted at a tertiary care facility in which 100 male volunteers aged ≥ 35 years received three doses of vitamin D3 (120 000 IU each; supplemented group) fortnightly or placebo (control group). Hepatic fasting insulin sensitivity [homeostasis model assessment (HOMA), quantitative insulin-sensitivity check index, HOMA-2], postprandial insulin sensitivity [oral glucose insulin sensitivity (OGIS)], insulin secretion (HOMA%B, HOMA2-%B), lipid profile and blood pressure were measured at baseline and at 6 weeks' follow-up. Results: Seventy-one of the recruited subjects completed the study (35 in supplemented group, 36 in control group). There was an increase in OGIS with supplementation by per protocol analysis (P = 0.038; intention-to-treat analysis P = 0.055). The age- and baseline 25-hydroxyvitamin D level-adjusted difference in change in OGIS was highly significant (mean difference 41.1 ± 15.5; P = 0.01). No changes in secondary outcome measures (insulin secretion, basal indices of insulin sensitivity, blood pressure or lipid profile) were found with supplementation. Conclusion: The trial indicates that vitamin D3 supplementation improves postprandial insulin sensitivity (OGIS) in apparently healthy men likely to have insulin resistance (centrally obese but non-diabetic). © 2009 The Authors.

Author-supplied keywords

  • article
  • blood pressure
  • clinical article
  • clinical trial
  • colecalciferol
  • controlled clinical trial
  • controlled study
  • diabetes mellitus
  • diet restriction
  • double blind procedure
  • drug metabolism
  • follow up
  • homeostasis
  • human
  • insulin release
  • insulin resistance
  • insulin sensitivity
  • lipid blood level
  • male
  • obesity
  • randomized controlled trial
  • tertiary health care
  • vitamin supplementation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Nagpal J.

  • Pande J.N.

  • Bhartia A.

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free