A double-blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg-positive chronic hepatitis B.

  • Zeng M
  • Mao Y
  • Yao G
 et al. 
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Abstract

Four hundred and eighty Chinese subjects with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) were enrolled in a multicenter, double-blind, randomized, placebo-controlled study of adefovir dipivoxil (ADV) 10 mg once daily. There was a significant difference in reduction of serum hepatitis B virus (HBV) DNA after 12 weeks between subjects who received ADV and those who received the placebo (3.4 and 0.1 log10 copies/mL, respectively, P < .001). Further reductions in serum HBV DNA and increases in the proportion of subjects with an HBV DNA level of at most 10(5) copies/mL, with HBV DNA undetectable, and with ALT normalization were observed in ADV-treated subjects at week 52 (median HBV DNA reduction of 4.5 log(10) copies/mL, 67% with HBV DNA

Author-supplied keywords

  • Adenine
  • Adenine: analogs & derivatives
  • Adenine: therapeutic use
  • Adolescent
  • Adult
  • Antiviral Agents
  • Antiviral Agents: therapeutic use
  • China
  • China: epidemiology
  • Chronic
  • Chronic: drug therapy
  • Chronic: epidemiology
  • Chronic: virology
  • DNA
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Hepatitis B
  • Hepatitis B e Antigens
  • Hepatitis B e Antigens: immunology
  • Hepatitis B virus
  • Hepatitis B virus: genetics
  • Hepatitis B virus: immunology
  • Humans
  • Immunosuppressive Agents
  • Incidence
  • Male
  • Middle Aged
  • Organophosphonates
  • Organophosphonates: therapeutic use
  • Treatment Outcome
  • Viral
  • Viral: genetics

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Authors

  • MinDe Zeng

  • YiMin Mao

  • GuangBi Yao

  • Hao Wang

  • JinLin Hou

  • YaoZong Wang

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