Drosophila: a "model" model system to study neurodegeneration

  • Celotto A
  • Palladino M
  • 24

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

The fruit fly, Drosophila melanogaster, is a powerful model genetic organism that has been used since the turn of the previous century in the study of complex biological problems. In the last decade, numerous researchers have focused their attention on understanding neurodegenerative diseases by utilizing this model system. Numerous Drosophila mutants have been isolated that profoundly affect neural viability and integrity of the nervous system with age. Additionally, many transgenic strains have been developed as models of human disease conditions. We review the existing Drosophila neurodegenerative mutants and transgenic disease models, and discuss the role of the fruit fly in therapeutic development for neurodegenerative diseases.

Author-supplied keywords

  • *Disease Models, Animal
  • *Neurodegenerative Diseases/drug therapy/genetics
  • Animals
  • Animals, Genetically Modified
  • Drosophila/*genetics/physiology
  • Humans
  • Mutation
  • Research Support, N.I.H., Extramural

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Authors

  • a M Celotto

  • M J Palladino

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free