A {DTaP-IPV//PRP{\textasciitilde}T} vaccine (Pentaxim): a review of 16 years' clinical experience

  • Plotkin S
  • Liese J
  • Madhi S
 et al. 
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Abstract

Owing to their low reactogenicity, confirmed efficacy and availability in combination vaccines, acellular pertussis ({aP)-inactivated} poliovirus ({IPV)} combined vaccines are now included in various national immunization programs worldwide. We provide an overview of 16 years of clinical experience with a diphtheria (D), tetanus (T), {aP}, {IPV} and Haemophilus influenzae type b (Hib) polysaccharide conjugated to tetanus protein ({PRP{\textasciitilde}T)} combined vaccine ({DTaP-IPV//PRP{\textasciitilde}T} - Pentaxim, Sanofi Pasteur, France). Good immunogenicity has been demonstrated after primary vaccination with Pentaxim, regardless of the population ethnicity and primary vaccination schedule. A booster vaccination in the second year of life also resulted in a high immune response for each antigen. Furthermore, 10 years of national surveillance in Sweden has demonstrated the effectiveness of Pentaxim in controlling pertussis. As is the case for other {aP-containing} combined vaccines, Pentaxim is well tolerated, with the safety profile being better than for whole-cell pertussis-containing combination vaccines for primary and booster vaccinations.

Author-supplied keywords

  • 0 (Diphtheria-Tetanus-acellular Pertussis Vaccine
  • 0 (Haemophilus Vaccines)
  • 0 (Haemophilus influenza type b polysaccharide va
  • 0 (Tetanus Toxoid)
  • 0 (Vaccines
  • Child
  • Combined)
  • Combined/ad [Administration & Dosage]
  • Combined/ae [Adverse Effects]
  • Combined/im [Immunology]
  • Combined/tu [Therapeutic Use]
  • Conjugate)
  • Conjugate/ad [Administration & Dosage]
  • Conjugate/ae [Adverse Effects]
  • Conjugate/im [Immunology]
  • Conjugate/tu [Therapeutic Use]
  • Diphtheria-Tetanus-acellular Pertussis Vaccines/a
  • Diphtheria-Tetanus-acellular Pertussis Vaccines/t
  • Haemophilus Vaccines/ad [Administration & Dosage]
  • Haemophilus Vaccines/ae [Adverse Effects]
  • Haemophilus Vaccines/tu [Therapeutic Use]
  • Humans
  • Immunization Schedule
  • Infant
  • Newborn
  • Preschool
  • Sweden
  • Tetanus Toxoid/ad [Administration & Dosage]
  • Tetanus Toxoid/ae [Adverse Effects]
  • Tetanus Toxoid/tu [Therapeutic Use]
  • Vaccines
  • vaccination
  • {*Diphtheria-Tetanus-acellular} Pertussis Vaccines
  • {*Haemophilus} Vaccines/im [Immunology]
  • {*Tetanus} Toxoid/im [Immunology]
  • {*Vaccines}

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Authors

  • Stanley A Plotkin

  • Johannes Liese

  • Shabir A Madhi

  • Esteban Ortiz

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