Dual Role of Wingless Signaling in Stem-like Hematopoietic Precursor Maintenance in Drosophila

  • Sinenko S
  • Mandal L
  • Martinez-Agosto J
 et al. 
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Abstract

In Drosophila, blood development occurs in a specialized larval hematopoietic organ, the lymph gland (LG), within which stem-like hemocyte precursors or prohemocytes differentiate to multiple blood cell types. Here we show that components of the Wingless (Wg) signaling pathway are expressed in prohemocytes. Loss- and gain-of-function analysis indicates that canonical Wg signaling is required for maintenance of prohemocytes and negatively regulates their differentiation. Wg signals locally in a short-range fashion within different compartments of the LG. In addition, Wg signaling positively regulates the proliferation and maintenance of cells that function as a hematopoietic niche in Drosophila, the posterior signaling center (PSC), and in the proliferation of crystal cells. Our studies reveal a conserved function of Wg signaling in the maintenance of stem-like blood progenitors and reveal an involvement of this pathway in the regulation of hemocyte differentiation through its action in the hematopoietic niche. © 2009 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • DEVBIO
  • STEMCELL

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Authors

  • Sergey A. Sinenko

  • Lolitika Mandal

  • Julian A. Martinez-Agosto

  • Utpal Banerjee

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