Dynamic electromechanical hydrogel matrices for stem cell culture

  • Lim H
  • Chuang J
  • Tran T
 et al. 
  • 64


    Mendeley users who have this article in their library.
  • 40


    Citations of this article.


Hydrogels have numerous biomedical applications including synthetic matrices for cell culture and tissue engineering. Here we report the development of hydrogel based multifunctional matrices that not only provide three-dimensional structural support to the embedded cells but also can simultaneously provide potentially beneficial dynamic mechanical and electrical cues to the cells. A unique aspect of these matrices is that they undergo reversible, anisotropic bending dynamics in an electric field. The direction and magnitude of this bending can be tuned through the hydrogel crosslink density while maintaining the same electric potential gradient, allowing control over the mechanical strain imparted to the cells in a three-dimensional environment. The conceptual design of these hydrogels was motivated through theoretical modeling of the osmotic pressure changes occurring at the gel-solution interfaces in an electric field. These electro-mechanical matrices support survival, proliferation, and differentiation of stem cells. Thus, these new three-dimensional in vitro synthetic matrices, which mimic multiple aspects of the native cellular environment, take us one step closer to in vivo systems.

Author-supplied keywords

  • biomaterials
  • electric field
  • osmotic pressure
  • polyelectrolyte hydrogels
  • stem cells

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Han L. Lim

  • Jessica C. Chuang

  • Tuan Tran

  • Aereas Aung

  • Gaurav Arya

  • Shyni Varghese

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free