Dynamic range of safe electrical stimulation of the retina

  • Butterwick A
  • Vankov A
  • Huie P
 et al. 
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Invitro retinal cells used. Damage measured using Propidium Iodide fluroescent staing Damage function of electrode size, charge denisty, time 1) Current density exponentially decreased with time. with 7500 pulses about 1/10th that of single pulse. Range ~ 10A/cm 2 to 100mA/cm 2 2) Current density decreased 1/x with pipette diameter with .1mm = 1.8A/cm 2 and .7 mm = 0.2A/cm 2 3) Current densisty decreased exponentially with pulse duration with 10us at 1A/cm 2 to 1/10 for 1ms, Furthermore larger diameter had higher Current density: 500um (10-3A/cm 2) 1mm (1A/cm 2) Safe charge deliver: Charge density damage limit is 100uC/cm 2 for 0.01cm 2 electrode and 6uC/cm 2/phase, (12 uC/cm 2) - for 0.5 cm 2 electrode

Author-supplied keywords

  • damage threshold
  • electrical stimulation
  • propidium iodide
  • retinal prostheses

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  • Alexander F Butterwick

  • Alexander Vankov

  • Phil Huie

  • Daniel V Palanker

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