Dynamics of DNA methylation during development.

  • Brandeis M
  • Ariel M
  • Cedar H
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DNA methylation plays a role in the repression of gene expression in animal cells. In the mouse preimplantation embryo, most genes are unmethylated but a wave of de novo methylation prior to gastrulation generates a bimodal pattern characterized by unmethylated CpG island-containing housekeeping genes and fully modified tissue-specific genes. Demethylation of individual genes then takes place during cell type specific differentiation, and this demodification may be a required step in the process of transcriptional activation. DNA modification is also involved in the maintenance of gene repression on the inactive X chromosome in female somatic cells and the marking of parental alleles at genomically imprinted gene loci.

Author-supplied keywords

  • Animals
  • Base Sequence
  • Blastocyst
  • DNA
  • DNA Replication
  • Embryo, Mammalian
  • Embryonic and Fetal Development
  • Female
  • Fertilization
  • Gastrula
  • Male
  • Methylation
  • Mice
  • Molecular Sequence Data
  • Muridae
  • Oocytes
  • Spermatozoa
  • chemistry
  • metabolism
  • physiology

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  • M Brandeis

  • M Ariel

  • H Cedar

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