Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis

  • Feuillet L
  • Reuter F
  • Audoin B
 et al. 
  • 13


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Cognitive impairment in patients with multiple sclerosis (MS) is a common occurrence and is generally fairly circumscribed. The prevalence of the cognitive deficits usually encountered could vary with the clinical course of the disease. To investigate whether the presence of cognitive impairment may occur in the very early stage of MS, we assessed the cognitive status of a group of 40 patients presenting with a recently diagnosed clinically isolated syndrome suggestive of MS (CISSMS), in comparison with 30 age-, sex-, and educational level-matched healthy control subjects. An extensive battery of neuropsychological tests was used to explore verbal and non-verbal memory, attention, concentration, speed of information processing, language and abstract reasoning. Patients with CISSMS had a significant, frequent (57%), and circumscribed cognitive impairment, focused on memory, speed of information processing, attention and executive functions.

Author-supplied keywords

  • biomedical research
  • clinically isolated syndrome
  • cognitive impairment
  • multiple
  • neurobehavioral manifestations
  • neuropsychological tests
  • pasat
  • sclerosis

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • L Feuillet

  • F Reuter

  • B Audoin

  • I Malikova

  • K Barrau

  • a a. Cherif

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free