Early events governing memory CD8+ T-cell differentiation

  • Obar J
  • Lefrancois L
  • 19

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Abstract

Understanding the regulation of the CD8(+) T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD8(+) T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of those signals and how early events regulate the fate decisions of the responding CD8(+) T cells. This review will discuss the recent findings about both the extracellular and intracellular factors that regulate the destiny of responding CD8(+) T cells.

Author-supplied keywords

  • *Cell Differentiation
  • Animals
  • CD8-Positive T-Lymphocytes/*cytology/*immunology
  • Humans
  • Immunologic Memory
  • Models, Biological

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Authors

  • J J Obar

  • L Lefrancois

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