Eat less, live longer? New insights into the role of caloric restriction in the brain

  • Levenson C
  • Rich N
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Abstract

Caloric restriction has wide-ranging health benefits and may offer protection against age-related neuronal loss and neurodegenerative disorders such as Alzheimer's disease, possibly via enhanced adult neurogenesis. While a variety of interventions such as exercise increase neurogenesis, recent work suggests that exercise and caloric restriction may work to enhance neurogenesis by different neurobiological mechanisms, suggesting a role for both diet and exercise in disease prevention.

Author-supplied keywords

  • Brain-derived neurotrophic factor
  • Dietary restriction
  • N-methyl-D-aspartate
  • Neurogenesis
  • Neurological diseases
  • Neurotrophins
  • Stem cells

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Authors

  • Cathy W. Levenson

  • Nicholas J. Rich

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