Effect of atrial fibrillation ablation on gastric motility: the atrial fibrillation gut study

  • Lakkireddy D
  • Reddy Y
  • Atkins D
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


BACKGROUND: Collateral damage to the vagal nerve and the upper gastrointestinal (UGI) system during atrial fibrillation ablation has not been systematically evaluated. METHODS AND RESULTS: We performed a prospective, observational study assessing the effect of atrial fibrillation ablation on the function of the vagus nerve/UGI system. All patients underwent esophageal manometry, gastric emptying study, and sham-feeding test (corresponding to esophageal, gastric, and small intestinal function evaluation, respectively) before ablation (baseline) and subsequently at 24 hours, 90 days, and 180 days after the procedure. In addition, UGI symptom assessment using the patient assessment of upper gastrointestinal disorders-symptom severity index (PAGI-SYM) questionnaire was performed at baseline and during each of the subsequent evaluations. Of the 27 patients enrolled in the study, 9 (33%) patients had abnormal UGI function at baseline; defined as at least one of the 3 abnormal tests. At 24 hours after the radiofrequency catheter ablation, 20 (74%) patients had at least 1 new abnormality on the UGI function tests (P

Author-supplied keywords

  • *Gastrointestinal Motility
  • Aged
  • Atrial Fibrillation/diagnosis/physiopathology/*sur
  • Catheter Ablation/*adverse effects
  • Esophageal Motility Disorders/diagnosis/*etiology/
  • Esophagus/*innervation
  • Female
  • Gastric Emptying
  • Gastroparesis/diagnosis/*etiology/physiopathology
  • Humans
  • Intestine, Small/*innervation
  • Kansas
  • Male
  • Manometry
  • Middle Aged
  • Prospective Studies
  • Stomach/*innervation
  • Time Factors
  • Treatment Outcome
  • Vagus Nerve Injuries/diagnosis/*etiology/physiopat

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • D Lakkireddy

  • Y M Reddy

  • D Atkins

  • J Rajasingh

  • A Kanmanthareddy

  • M Olyaee

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free