Effect of Brain-Derived Neurotrophic Factor Treatment and Forced Arm Use on Functional Motor Recovery after Small Cortical Ischemia

  • Schäbitz W
  • Berger C
  • Kollmar R
 et al. 
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Abstract

BACKGROUND AND PURPOSE Both the administration of growth factors and physical therapy such as forced arm use (FAU) are promising approaches to enhance recovery after stroke. We explored the effects of these therapies on behavioral recovery and molecular markers of regeneration after experimental ischemia. METHODS Rats were subjected to photothrombotic ischemia: sham (no ischemia), control (ischemia), brain-derived neurotrophic factor (BDNF; ischemia plus BDNF, 20 microg), and FAU (ischemia plus FAU, 1-sleeve plaster cast ipsilateral limb). Animals survived 1 or 6 weeks and underwent behavioral testing (Rotarod, beam balance, adhesive removal, plantar test, neuroscore). After the rats were killed, brain sections were immunostained for semiquantitative analysis of MAP1B, MAP2, synaptophysin, GFAP expression, and quantification of infarct volumes. RESULTS Infarct volumes were not different between the groups 1 or 6 weeks after ischemia. BDNF-treated animals had better functional motor recovery (Rotarod, beam balance, neuroscore) compared with all other groups (P

Author-supplied keywords

  • Brain-derived neurotrophic factor
  • Cerebral ischemia
  • Forced arm use
  • Photothrombosis
  • Regeneration

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Authors

  • Wolfe Rüdiger Schäbitz

  • C. Berger

  • R. Kollmar

  • M. Seitz

  • E. Tanay

  • M. Kiessling

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