Effect of endogenous angiotensin II on renal nerve activity and its cardiac baroreflex regulation

  • Dibona G
  • Jones S
  • Sawin L
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Abstract

The effects of physiologic alterations in endogenous angiotensin II activity on basal renal sympathetic nerve activity and its cardiac baroreflex regulation were studied. The effect of angiotensin II type 1 receptor blockade with intracerebroventricular losartan was examined in conscious rats consuming a low, normal, or high sodium diet that were instrumented for the simultaneous measurement of right atrial pressure and renal sympathetic nerve activity. The gain of cardiac baroreflex regulation of renal sympathetic nerve activity (% delta renal sympathetic nerve activity/mmHg mean right atrial pressure) was measured during isotonic saline volume loading. Intracerebroventricular losartan did not decrease arterial pressure but significantly decreased renal sympathetic nerve activity in low (-36+/-6%) and normal (-24+/-5%), but not in high (-2+/-3%) sodium diet rats. Compared with vehicle treatment, losartan treatment significantly increased cardiac baroreflex gain in low (-3.45+/-0.20 versus -2.89+/-0.17) and normal (-2.89+/-0.18 versus -2.54+/-0.14), but not in high (-2.27+/-0.15 versus -2.22+/-0.14) sodium diet rats. These results indicate that physiologic alterations in endogenous angiotensin II activity tonically influence basal levels of renal sympathetic nerve activity and its cardiac baroreflex regulation.

Author-supplied keywords

  • Angiotensin II/*physiology
  • Animals
  • Antihypertensive Agents/pharmacology
  • Baroreflex/*physiology
  • Blood Pressure/drug effects
  • Diet, Sodium-Restricted
  • Heart Rate/drug effects
  • Heart/*physiology
  • Injections, Intraventricular
  • Kidney/*innervation
  • Losartan/pharmacology
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Sympathetic Nervous System/drug effects/*physiolog

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Authors

  • G F Dibona

  • S Y Jones

  • L L Sawin

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