Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: a cohort study.

  • Badri M
  • Wilson D
 et al. 
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Abstract

BACKGROUND: Studies of the effect of highly active antiretroviral therapy (HAART) on the risk of HIV-1-associated tuberculosis have had variable results. We set out to determine the effect of HAART on the risk of tuberculosis in South Africa. METHODS: We compared the risk of tuberculosis in 264 patients who received HAART in phase III clinical trials and a prospective cohort of 770 non-HAART patients who were attending Somerset Hospital adult HIV clinic, University of Cape Town, between 1992 and 2001. Poisson regression models were fitted to determine risk of tuberculosis; patients were stratified by CD4 count, WHO clinical stage, and socioeconomic status. FINDINGS: HAART was associated with a lower incidence of tuberculosis (2.4 vs 9.7 cases per 100 patient-years, adjusted rate ratio 0.19 [95% CI 0.9-0 38]; p

Author-supplied keywords

  • AIDS-Related Opportunistic Infections
  • AIDS-Related Opportunistic Infections: epidemiolog
  • AIDS-Related Opportunistic Infections: prevention
  • Adult
  • Antiretroviral Therapy
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Female
  • HIV-1
  • Highly Active
  • Humans
  • Incidence
  • Male
  • Poisson Distribution
  • Poverty
  • South Africa
  • South Africa: epidemiology
  • Tuberculosis
  • Tuberculosis: epidemiology
  • Tuberculosis: prevention & control

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Authors

  • Motasim Badri

  • Motasim Badri

  • Douglas Wilson

  • Douglas Wilson

  • Robin Wood

  • Robin Wood

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