Effect of increased body mass index and anaesthetic duration on recovery of protective airway reflexes after sevoflurane vs desflurane

  • McKay R
  • Malhotra A
  • Cakmakkaya O
 et al. 
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BACKGROUND: Increased BMI may increase the body's capacity to store potent inhaled anaesthetics, more so with more soluble agents. Accordingly, we asked whether increased BMI and longer anaesthesia prolonged airway reflex recovery. METHODS: We measured time from anaesthetic discontinuation until first response to command (T1); from response to command until ability to swallow (T2); and from anaesthetic discontinuation to recovery of ability to swallow (T3) in 120 patients within three BMI ranges (18-24, 25-29, and >or=30 kg m(-2)). All received sevoflurane or desflurane, delivered via an LMA. RESULTS: T1 and T3 after sevoflurane exceeded T1 and T3 after desflurane: 6.6 (sd 4.2) vs 4.0 (1.9) min (Por=30 kg m(-2) were less often able to swallow 2 min after response to command than were those with BMI 18-24 or 25-29 kg m(-2) (3/20 vs 10/20 or 9/20, P

Author-supplied keywords

  • Airway, reflexes
  • Anaesthetics, desflurane
  • Anaesthetics, sevoflurane
  • Anaesthetics, volatile
  • Pharmacokinetics, obesity
  • Pharmacokinetics, uptake

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  • R. E. McKay

  • A. Malhotra

  • O. S. Cakmakkaya

  • K. T. Hall

  • W. R. McKay

  • C. C. Apfel

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