The effect of intraoperative heparin administered during total hip arthroplasty on the incidence of proximal deep vein thrombosis assessed by magnetic resonance venography

  • Westrich G
  • Salvati E
  • Sharrock N
 et al. 
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Intraoperative, unfractionated heparin, administered intravenously before the femoral work, has demonstrated to be effective in reducing the strong thrombotic stimulus that occurs during total hip arthroplasty (THA) surgery. This randomized, double-blind, prospective study included only THA patients with significant comorbidities predisposing them to deep vein thrombosis (DVT). The 2 groups consisted of study patients who received a single dose of intravenous, intraoperative, unfractionated heparin and control patients who received a single dose of intravenous, intraoperative saline. Magnetic resonance venography was used as the DVT diagnostic tool. The overall prevalence of proximal femoral vein clots was 2.2% (3 of 134), whereas pelvic thrombosis was detected in 10.4% (14 of 134). This study demonstrated that pelvic thrombi may form following THA and that a single dose of intraoperative heparin does not prevent their formation, but may be effective at preventing ipsilateral femoral thrombi. This study strongly supports a multimodal approach to DVT prophylaxis following THA. © 2005 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • intraoperative unfractionated heparin
  • magnetic resonance venography
  • proximal deep vein thrombosis
  • thromboembolism
  • total hip arthroplasty

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  • Geoffrey H. Westrich

  • Eduardo A. Salvati

  • Nigel Sharrock

  • Hollis G. Potter

  • Pamela M. Sánchez

  • Thomas P. Sculco

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