The effect of liver disease on inhibitory and plasma protein-binding displacement interactions: an update

  • Palatini P
  • Orlando R
  • De Martin S
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Abstract

Inhibition of CYP-mediated metabolism is the most frequent and dangerous drug interaction, which causes serious problems in drug development, drug approval and clinical practice. The wide interindividual variability in the magnitude of such interactions constitutes the main hurdle to their management by dose adjustment. AREA COVERED IN THIS REVIEW: This review focuses on a recently identified source of variability in the extent of inhibitory drug interactions, namely liver functional status. It examines the differential effect of liver dysfunction on reversible and mechanism-based CYP inhibition, as well as on inhibition accompanied by plasma protein-binding displacement.

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Authors

  • Pietro Palatini

  • Rocco Orlando

  • Sara De Martin

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