The effect of liver disease on inhibitory and plasma protein-binding displacement interactions: an update

  • Palatini P
  • Orlando R
  • De Martin S
  • 7


    Mendeley users who have this article in their library.
  • 9


    Citations of this article.


Inhibition of CYP-mediated metabolism is the most frequent and dangerous drug interaction, which causes serious problems in drug development, drug approval and clinical practice. The wide interindividual variability in the magnitude of such interactions constitutes the main hurdle to their management by dose adjustment. AREA COVERED IN THIS REVIEW: This review focuses on a recently identified source of variability in the extent of inhibitory drug interactions, namely liver functional status. It examines the differential effect of liver dysfunction on reversible and mechanism-based CYP inhibition, as well as on inhibition accompanied by plasma protein-binding displacement.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Pietro Palatini

  • Rocco Orlando

  • Sara De Martin

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free