Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice

  • Capasso R
  • Izzo A
  • Borrelli F
 et al. 
  • 20


    Mendeley users who have this article in their library.
  • 38


    Citations of this article.


We have investigated the effect piperine on castor oil-stimulated fluid accumulation in the mouse small intestine. Piperine (2.5-20 mg/kg, i.p.) dose-dependently reduced castor oil-induced intestinal fluid accumulation. The inhibitory effect of piperine (10 mg/kg i.p.) was strongly attenuated in capsaicin (75 mg/kg in total, s.c.)-treated mice but it was not modified by the vanilloid receptor antagonist capsazepine (30 mg/kg i.p.). Pretreatment of mice with hexamethonium (1 mg/kg i.p.), naloxone (2 mg/kg i.p.), yohimbine (1 mg/kg i.p.) or the cannabinoid CB1receptor antagonist SR141716A (0.3 mg/kg i.p.) did not modify the inhibitory effect of piperine (10 mg/kg i.p.). These results suggest that piperine reduces castor oil-induced fluid secretion with a mechanism involving capsaicin-sensitive neurons, but not capsazepine-sensitive vanilloid receptors. © 2002 Elsevier Science Inc. All rights reserved.

Author-supplied keywords

  • Capsaicin
  • Capsazepine
  • Fluid accumulation
  • Intestinal secretion
  • Piperine
  • Small intestine
  • Vanilloid receptors

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Aldo PintoUniversity of Salerno

  • Raffaele Capasso

  • Angelo A. Izzo

  • Francesca Borrelli

  • Alessandra Russo

  • Lidia Sautebin

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free