Effect of a prepregnancy pertussis booster dose on maternal antibody titers in young infants

  • Leuridan E
  • Hens N
  • Peeters N
 et al. 
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Abstract

To examine the influence of a pertussis booster vaccination on the transfer of maternal antibodies, 24 nonpregnant women received a tetanus, diphtheria, acellular pertussis booster vaccine between 2 consecutive pregnancies. Blood was drawn from mothers and off-spring. Efficient transplacental antibody transfer and significantly higher antibody titers against 3 pertussis antigens were observed in cord blood and in blood of 1-month-old infants born after a maternal booster vaccination compared with results in their siblings born before the booster administration.

Author-supplied keywords

  • booster vaccination
  • maternal antibodies
  • neonatal pertussis

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