The effect of renin-angiotensin-aldosterone system blockade on contrast-induced acute kidney injury: A propensity-matched study

  • Rim M
  • Ro H
  • Kang W
 et al. 
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Abstract

Background: The role of the angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) in the pathophysiology of contrast-induced acute kidney injury (AKI) is controversial, and the available literature is contradictory. Study Design: A retrospective propensity score-matched study to analyze the effect of ACE-inhibitor/ARB therapy on the development of contrast-induced AKI. Setting & Participants: Using propensity score matching, 1,322 ACE-inhibitor/ARB recipients and nonrecipients were paired for analysis from 5,299 patients and fulfilled the inclusion criteria among 11,447 patients receiving coronary angiography (CAG) or percutaneous coronary intervention. Predictors: ACE-inhibitor/ARB use based on prescription and risk factors for contrast-induced AKI. Outcomes: The incidence of contrast-induced AKI defined by AKI Network (AKIN) criteria: an absolute increase in serum creatinine levels

Author-supplied keywords

  • Contrast-induced acute kidney injury (AKI)
  • angiotensin-converting enzyme (ACE) inhibitor/angiotensin receptor blocker (ARB)
  • coronary angiography

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Authors

  • Min Young Rim

  • Han Ro

  • Woong Chol Kang

  • Ae Jin Kim

  • Hyeonsu Park

  • Jae Hyun Chang

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