Effect of smoking on concentrations of receptor activator of nuclear factor kappa B ligand and osteoprotegerin in human gingival crevicular fluid.

  • Tang T
  • Fitzsimmons T
  • Bartold P
  • 13

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Abstract

AIM: To compare the levels of the soluble receptor activator of nuclear factor kappa B ligand (sRANKL), osteoprotegerin (OPG) and their relative ratio in gingival crevicular fluid (GCF) among periodontitis patients with varying smoking histories. MATERIAL AND METHODS: GCF samples were collected from 149 periodontitis patients who were never smokers (n=58), former smokers (n=39) and current smokers (n=52). sRANKL and OPG concentrations in GCF were measured by enzyme-linked immunosorbent assays. RESULTS: sRANKL, OPG and their relative ratio were not statistically significant among the never smokers, former smokers and current smokers. However, OPG was significantly reduced and subsequently the sRANKL:OPG ratio was significantly increased in the high pack-years group as compared with never smokers. The positive correlation between pack-years and the sRANKL:OPG ratio remained statistically significant after adjusting for age and current smoking status. CONCLUSION: Increased lifetime exposure to cigarette smoking above a minimum threshold suppresses OPG production and leads to increased sRANKL:OPG. This may partially explain increased bone loss in smoking-related periodontitis.

Author-supplied keywords

  • 80 and over
  • Adult
  • Age Factors
  • Aged
  • Alveolar Bone Loss
  • Alveolar Bone Loss: etiology
  • Case-Control Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gingival Crevicular Fluid
  • Gingival Crevicular Fluid: chemistry
  • Humans
  • Male
  • Middle Aged
  • Osteoprotegerin
  • Osteoprotegerin: analysis
  • Osteoprotegerin: biosynthesis
  • Periodontitis
  • Periodontitis: metabolism
  • RANK Ligand
  • RANK Ligand: analysis
  • RANK Ligand: metabolism
  • Smoking
  • Smoking: adverse effects

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Authors

  • Teck H Tang

  • Tracy R Fitzsimmons

  • P Mark Bartold

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