Effects of antidepressant treatment following myocardial infarction

  • van Melle J
  • de Jonge P
  • Honig A
 et al. 
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BACKGROUND: Depression following myocardial infarction is associated with poor cardiac prognosis. It is unclear whether antidepressant treatment improves long-term depression status and cardiac prognosis. AIMS: To evaluate the effects of antidepressant treatment compared with usual care in an effectiveness study. METHOD: In a multicentre randomised controlled trial, 2177 myocardial infarction patients were evaluated for ICD-10 depression and randomised to intervention (n=209) or care as usual (n=122). Both arms were evaluated at 18 months post-myocardial infarction for long-term depression status and new cardiac events. RESULTS: No differences were observed between intervention and control groups in mean scores on the Beck Depression Inventory (11.0, s.d.=7.5 v.10.2, s.d.=5.1, P=0.45) or presence of ICD-10 depression (30.5 v. 32.1%, P=0.68). The cardiac event rate was 14% among the intervention group and 13% among controls (OR=1.07, 95% CI 0.57-2.00). CONCLUSIONS: Antidepressant treatment did not alter long-term depression post-myocardial infarction status or improve cardiac prognosis

Author-supplied keywords

  • AN
  • CI
  • Cardiology
  • Control Groups
  • Group
  • IM
  • IS
  • Netherlands
  • Patients
  • Prognosis
  • Research
  • Research Support
  • Support
  • TO
  • Treatment
  • Universities
  • antidepressant
  • cardiac
  • depression
  • intervention
  • medical
  • myocardial infarction

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  • J P van Melle

  • P de Jonge

  • A Honig

  • A H Schene

  • A M Kuyper

  • H J Crijns

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