Effects of anti-hypertensive drugs on esophageal body contraction

  • Yoshida K
  • Furuta K
  • Adachi K
 et al. 
  • 8


    Mendeley users who have this article in their library.
  • 13


    Citations of this article.


AIM: To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possible relationship with gastro-esophageal reflux disease. METHODS: Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine, losartan, and atenolol, as well as without any drug administration. RESULTS: Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were significantly higher than those without medication in a supine position. On the other hand, peristaltic pressures under nifedipine administration were lower than those observed without drug administration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition, while the effects of nifedipine were the opposite. CONCLUSION: Among the anti-hypertensive drugs tested, atenolol enhanced esophageal motor activity, which was in contrast to nifedipine. © 2010 Baishideng. All rights reserved.

Author-supplied keywords

  • ??1 blocker
  • Anti-hypertensive drug
  • Calcium-channel blocker
  • Esophageal body contraction
  • High-resolution manometry
  • Lower esophageal sphincter

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Koichi Yoshida

  • Kenji Furuta

  • Kyoichi Adachi

  • Shunji Ohara

  • Terumi Morita

  • Takashi Tanimura

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free