See, stats, and : https : / / www . researchgate . net / publication / 7078237 Effects - like response Article : PR Source : PubMed CITATIONS 53 READS 229 3 , including : Some : " Innovative (OVOCURA) " - Task . Assessing (POIG . 03 . 01 - 00 - 133 / 08) View Maria Wroclaw 47 SEE Halina Wroclaw 8 SEE All . The . All - text and , letting . Abstract : Several pieces of anatomical , biochemical and pharmacological evidence indicate that the endocannabinoid system via CB receptors is implicated in the control of emotional behavior . However , previous studies have reported unclear and contradictory results concerning the role of cannabinoids in anxiety . The aim of the present study was to examine the influence of the cannabinoid agonist WIN 55 , 212 - 2 (1 and 5 mg / kg) , the CB antagonist AM 281 (1 , 2 and 4 mg / kg) , the inhibitor of anandamide hydrolysis AACOCF ! (1 and 4 mg / kg) and the inhibitor of anandamide transporter AM 404 (1 and 4 mg / kg) on the anxiety - like response in mice in the light / dark box test . WIN 55 , 212 - 2 (5 mg / kg) induced the anxiogenic - like effect accompanied by motor inhibition , AACOCF ! (4 mg / kg) induced the selective anxiolytic - like effect , whereas AM 404 and AM 281 were without effect . Pretreatment with AM 281 (2 mg / kg) blocked the anxiogenic - like and sedative responses induced by WIN 55 , 212 - 2 , as well as the anxiolytic - like effect of AACOCF ! . These results support the hypothesis that the endocannabinoid system is involved in the regulation of anxiety - like behavior , and also suggest that the inhibitors of anandamide hydrolysis might be potential anxiolytic drugs .
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