Effects of chronic haloperidol and clozapine treatment on AMPA and kainate receptor binding in rat brain

  • Schmitt A
  • May B
  • Muller B
 et al. 
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Background: Alterations in AMPA and kainate receptor binding have been
revealed in post-mortem schizophrenic brains. As most patients had been
treated with antipsychotics, medication effects cannot be excluded as a
possible explanation for these results. Methods: Within the framework of
this animal study, we investigated {[}H-3]AMPA and {[}H-3]kainate
receptor binding in different rat brain regions following 6 months of
oral treatment with either haloperidol (1.5 mg/kg/day) or clozapine (45
mg/kg/ day). Results: AMPA receptor binding was increased after
haloperidol treatment in the striatum, nucleus accumbens, cingulate
cortex, and insular cortex. Clozapine showed increased AMPA receptor
binding only in the anterior cingulate cortex. Kainate receptor binding
was increased by both drugs in all hippocampal subfields. Conclusions:
This altered receptor binding may be related to beneficial neuroleptic
effects and side effects. Furthermore, neuroleptic therapy may
contribute to some of the postmortem findings in the striatum in

Author-supplied keywords

  • haloperidol; clozapine; glutamate receptor; AMPA;

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  • A Schmitt

  • B May

  • B Muller

  • A Jatzko

  • G Petroianu

  • D F Braus

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