Effects of hypertonic saline on myocardial blood flow in a porcine model of prolonged cardiac arrest

  • Fischer M
  • Dahmen A
  • Standop J
 et al. 
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Abstract

Objective: To evaluate the effects of hypertonic saline (HS) on myocardial reperfusion pressure (MPP) and blood flow (MBF), and cardiac index (CI) during and after cardiopulmonary resuscitation (CPR). Methods: In 21 domestic swine (16-23 kg) open chest cardiac massage was initiated after 10 min of ventricular fibrillation. With the onset of CPR animals randomly received HS (7.2%; 2 ml/kg per 10 min or 4 ml/kg per 20 min) or normal saline ((NS); 2 ml/kg per 10 min). Haemodynamic variables were monitored continuously, and coloured microspheres were used to measure MBF and CI before cardiac arrest (CA), during CPR and 5, 30 and 120 min after the return of spontaneous circulation. Results: During CPR HS significantly increased MPP, MBF, and CI in comparison to NS (P

Author-supplied keywords

  • Cardiac arrest
  • Cardiac output
  • Cardiopulmonary resuscitation
  • Fluid therapy
  • Hypertonic saline
  • Myocardial blood flow
  • Post-resuscitation period

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Authors

  • Matthias Fischer

  • Alfred Dahmen

  • Jens Standop

  • Andreas Hagendorff

  • Andreas Hoeft

  • Henning Krep

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