Effects of prenatal exposure to ethanol on callosal projection neurons in rat somatosensory cortex.

  • Miller M
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

The distribution and density of callosal projection neurons in the
somatosensory cortex of mature rats was altered by prenatal exposure
to ethanol. The density of callosal neurons was significantly greater
in ethanol-treated rats than in controls. Ethanol exposure also altered
the laminar distribution of callosal projection neurons. Whereas
in control rats the cell bodies of callosal projection neurons were
in layers II/III and V, in ethanol-treated rats most of these neurons
were distributed in layers V and VI. Many of the ectopic neurons
were generated toward the end of cortical neuronogenesis (i.e., on
gestational day 20). This contrasts with controls wherein co-generated
cohorts were distributed in layer II/III. Thus, the connectional
phenotype of the callosal projection neurons is retained regardless
of its laminar residence. These ethanol-induced abnormalities apparently
result from defects in neuronal migration and axonal pruning.

Author-supplied keywords

  • Animal; Ethanol
  • Animals; Axons
  • Inbred Strains; Somatosensory Cortex
  • cytology/drug effects/embryology; Disease Models
  • cytology/drug effects/embryology; Staining and La
  • cytology/drug effects/ultrastructure; Oxazines; P
  • drug effects; Cell Movement
  • drug effects; Central Nervous System Depressants
  • drug effects; Neurons
  • pathology; Neural Pathways
  • pharmacology; Coloring Agents; Corpus Callosum
  • pharmacology; Female; Fetal Alcohol Syndrome

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 9359595

Authors

  • M W Miller

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free