The effects of pulsatile cardiopulmonary bypass on acute kidney injury.

  • Adademir T
  • Ak K
  • Aljodi M
 et al. 
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PURPOSE: Protective effect of pulsatile flow cardiopulmonary bypass (CPB) on the occurrence of acute renal injury is still a matter of debate. The objective of this study was to compare the effects of pulsatile and non-pulsatile cardiopulmonary bypass on kidneys using Urinary neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) as the markers of renal injury.

METHODS: 85 consecutive patients with normal preoperative renal function were prospectively enrolled in the study. Pulsatile perfusion (Group P) and non-pulsatile perfusion (Group NP) was used in 42 and 43 of the patients, respectively, during aortic cross-clamping period. NGAL and IL-18 were analyzed using ELISA in urine samples obtained preoperatively, and at 2, 12, and 24 h after CPB.

RESULTS: There was no significant difference between the groups in terms of perioperative renal function tests. IL-18 levels measured at 12 h after CPB were significantly lower in Group P, compared to Group NP (p
CONCLUSIONS: Low IL-18 and NGAL levels found in the pulsatile perfusion group might suggest the use of pulsatile flow resulted in better kidney protection.

Author-supplied keywords

  • Acute Kidney Injury
  • Acute Kidney Injury: diagnosis
  • Acute Kidney Injury: etiology
  • Acute Kidney Injury: prevention & control
  • Acute Kidney Injury: urine
  • Acute-Phase Proteins
  • Acute-Phase Proteins: urine
  • Adult
  • Aged
  • Aorta
  • Aorta: physiopathology
  • Aorta: surgery
  • Biological Markers
  • Biological Markers: urine
  • Cardiopulmonary Bypass
  • Cardiopulmonary Bypass: adverse effects
  • Cardiopulmonary Bypass: methods
  • Constriction
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukin-18
  • Interleukin-18: urine
  • Kidney Function Tests
  • Lipocalins
  • Lipocalins: urine
  • Male
  • Middle Aged
  • Prospective Studies
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins: urine
  • Pulsatile Flow
  • Time Factors
  • Treatment Outcome
  • Turkey

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  • Taylan Adademir

  • Koray Ak

  • Maher Aljodi

  • Mehmet Emre Elçi

  • Sinan Arsan

  • Selim Isbir

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