Abstract
The purpose of this study was to provide a cost-benefit analysis of topical tranexamic acid (TXA) in primary total hip and knee arthroplasty patients. A retrospective cohort of 591 consecutive patients, 311 experimental and 280 control, revealed a transfusion rate reduction from 17.5% to 5.5%, increased postoperative hemoglobin, and decreased delta hemoglobin without an increase in adverse events (all P
Author supplied keywords
- Acute Lung Injury
- Acute Lung Injury: etiology
- Adult
- Antifibrinolytic Agents
- Antifibrinolytic Agents: therapeutic use
- Arthroplasty
- Blood
- Blood Loss
- Blood Transfusion
- Blood Transfusion: adverse effects
- Blood Transfusion: methods
- Blood Transfusion: mortality
- Blood transfusion
- Blood-Borne Pathogens
- Cost comparative analysis
- Disease
- Female
- Financial
- Graft vs Host Disease
- Graft vs Host Disease: etiology
- Graft vs Host Disease: genetics
- Hip
- Humans
- Hypersensitivity
- Hypersensitivity: etiology
- Immunomodulation
- Immunomodulation: physiology
- Male
- Meta-analysis
- Middle Aged
- Morbidity
- Oral
- Orthopedic Procedures
- Perioperative Period
- Primary arthroplasty
- Primary joint arthroplasty
- Prospective Studies
- Replacement
- Shock
- Shock: etiology
- Surgical
- Surgical: prevention & control
- Total hip arthroplasty
- Total knee arthroplasty
- Tranexamic Acid
- Tranexamic Acid: therapeutic use
- Tranexamic acid
- Transfusion
- Venous Thromboembolism
- Venous Thromboembolism: etiology
- abdomen
- anemia
- antifibrinolytic
- arthroplasty of hip
- arthroplasty of knee
- blood loss
- blood transfusion
- complications
- cost saving
- femoral canal
- intravenous
- introduction to tranexamic acid
- is often associated with
- major elective orthopedic surgery
- meta-analysis
- mortality
- oral
- postop
- quality improvement
- requiring the
- surgical blood loss
- total hip arthroplasty
- total knee arthroplasty
- tranexamic acid
- transfusion
Cite
CITATION STYLE
Benoni, G., Fredin, H., Knebel, R., Nilsson, P., Carson, J. L., Duff, A., … Fan, Z. (2017). The effects of recombinant human erythropoietin on perioperative transfusion requirements in patients having a major orthopaedic operation. The American Erythropoietin Study Group. Journal of Arthroplasty, 78(1), 62–72. Retrieved from http://josr-online.biomedcentral.com/articles/10.1186/s13018-017-0660-6 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3474476&tool=pmcentrez&rendertype=abstract http://dx.doi.org/10.1016/j.arth.2014.01.031 http://jbjs.org/content/96/21/1836.ab
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