Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women

  • Imhof M
  • Gocan A
  • Reithmayr F
 et al. 
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Objective: To evaluate the effects of a non-prescription red clover extract (MF11 RCE, Melbrosin International, Vienna, Austria) on selected sex hormones and endometrium in postmenopausal women. Patients and methods: One-hundred and nine postmenopausal women with an age ≥40 years were randomly assigned to one of two groups either two capsules of MF11RCE (80 mg isoflavone) per day for a 90 day period, or placebo of equal design. After a 7 day washout period, medication was crossed-over for another 90 days. Results: Combined evaluation demonstrated that supplementation with MF11RCE (verum), in contrast to placebo, significantly increased plasma testosterone levels and decreased endometrial thickness. Conclusion: MF11RCE exerts a moderate effect on testosterone levels in postmenopausal women, while estradiol levels remained unchanged. The observed reduction of endometrial thickness provides further support for a safe role for isoflavones in terms of endometrial hyperplasia. © 2006 Elsevier Ireland Ltd. All rights reserved.

Author-supplied keywords

  • Endometrium
  • Isoflavones
  • Menopause
  • Phytoestrogens
  • Red clover
  • Sex hormones

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  • Martin Imhof

  • Anca Gocan

  • Franz Reithmayr

  • Markus Lipovac

  • Claudia Schimitzek

  • Peter Chedraui

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