Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in ventral premotor cortex.

  • Dancause N
  • Barbay S
  • Frost S
 et al. 
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Abstract

After a cortical lesion, cortical areas distant from the site of injury are known to undergo physiological and anatomical changes. However, the mechanisms through which reorganization of distant cortical areas is initiated are poorly understood. In a previous publication, we showed that the ventral premotor cortex (PMv) undergoes physiological reorganization after a lesion destroying the majority of the primary motor cortex (M1) distal forelimb representation (DFL). After large lesions destroying >50% of the M1 DFL, the PMv DFL invariably increased in size, and the amount of the increase was positively correlated with the size of lesion. To determine whether lesions destroying

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Authors

  • Numa Dancause

  • Scott Barbay

  • Shawn B Frost

  • Elena Zoubina

  • Erik J Plautz

  • Jonathan D Mahnken

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