Effects of tobacco smoking on cancer and cardiovascular disease in urban black South Africans

  • Stein L
  • Urban L
  • Weber M
 et al. 
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Abstract

Demographic and lifestyle information from 9690 black patients diagnosed with cancer or cardiovascular disease was collected in an ongoing case-control study in Johannesburg, South Africa. Compared to never smokers, the odds ratio (OR) for lung cancer among current smokers was 16.3 (95% confidence interval (CI), 9.6-27.6) for men and 6.4 (95% CI, 4.0-10.4) for women. The corresponding OR for other smoking-related cancers was 4.6 (95% CI, 3.7-5.7) among men and 1.9 (95% CI, 1.6-2.2) among women, and for cardiovascular disease, 3.4 (95% CI, 2.1-5.4) among men and 1.5 (95% CI, 1.1-2.1) among women. Risks were higher among smokers than former smokers, and all risk estimates increased with increasing levels of smoking duration and intensity. Non-electric domestic fuel was associated with approximately 60% increase in the risk of smoking-related cancer, but not cardiovascular disease. Risks for cancers of cervix, oesophagus, oral cavity/pharynx, stomach, larynx, pancreas and anogenital region, as well as squamous cell carcinoma of skin were all significantly higher among current than never-smokers, with ORs ranging from 1.5 for cervix (95% CI, 1.2-1.8) to 14.7 for larynx (95% CI, 7.2-30). The risks of tobacco-related disease reported here are similar to that currently observed in Western countries, even though cigarette consumption is relatively low in this population. © 2008 Cancer Research UK.

Author-supplied keywords

  • South Africa
  • adult
  • aged
  • article
  • cancer risk
  • cardiovascular disease
  • case control study
  • controlled study
  • demography
  • esophagus cancer
  • female
  • human
  • lifestyle
  • lung cancer
  • major clinical study
  • male
  • medical information
  • mouth cancer
  • neoplasm
  • pancreas cancer
  • pharynx cancer
  • priority journal
  • skin carcinoma
  • smoking
  • squamous cell carcinoma
  • stomach cancer
  • uterine cervix cancer

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Authors

  • L Stein

  • L.I Urban

  • M. Weber

  • P Ruff

  • M Hale

  • B Donde

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