Efficacy of Different Treatment Alternatives for Obesity Hypoventilation Syndrome. Pickwick Study

  • Masa J
  • Corral J
  • Alonso M
 et al. 
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Rationale: The incidence of obesity hypoventilation syndrome (OHS) may be increasing in parallel with the present obesity epidemic. Despite extensive noninvasive ventilation (NIV) and continuous positive airway pressure (CPAP) use in patients with OHS, information regarding efficacy is limited.Objectives: We performed a large, multicenter randomized controlled study to determine the comparative efficacy of NIV, CPAP, and lifestyle modification (control group) using daytime PaCO2 as the main outcome measure.Methods: Sequentially screened patients with OHS with severe sleep apnea were randomized into the above-mentioned groups for a 2-month follow up. Arterial blood gas parameters, clinical symptoms, health-related quality-of-life assessments, polysomnography, spirometry, 6-minute-walk distance, dropouts, compliance, and side effects were evaluated. Statistical analysis was performed using intention-to-treat analysis, although adjustments for CPAP and NIV compliance were also analyzed.Measurements and Main ...

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  • OHS

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  • Juan F Masa

  • Jaime Corral

  • Maria L Alonso

  • Estrella Ordax

  • Maria F Troncoso

  • Monica Gonzalez

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