Journal article

Efficacy of etidronate and sequential monofluorophosphate in severe postmenopausal osteoporosis: A pilot study

Ringe J, Dorst A, Faber H, Kipshoven C, Rovati L, Setnikar I ...see all

Rheumatology International, vol. 25, issue 4 (2005) pp. 296-300

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In a three-year pilot study on 52 women with severe postmenopausal osteoporosis, treatment with etidronate followed by calcium and vitamin D (ECaD) was compared to etidronate followed by monofluorophosphate, calcium and vitamin D (EFCaD). BMD in lumbar spine, total hip and femoral neck increased significantly more with EFCaD than with ECaD. Pain-mobility score decreased significantly more with EFCaD than with ECaD (p=0.006). New vertebral fractures occurred in three patients under EFCaD (12%) and in nine under ECaD (35%), (p=0.048). Three patients under EFCaD (12%) and 15 under ECaD (58%) did not respond to therapy (p of difference=0.001). Mild or moderate adverse reactions were reported by 25 patients, with no significant difference between the two groups. The pilot study suggests that etidronate, sequentially followed by monofluorophosphate, could be a safe, effective and relatively inexpensive therapy in severe postmenopausal osteoporosis. © Springer-Verlag 2005.

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  • J. D. Ringe

  • A. Dorst

  • H. Faber

  • C. Kipshoven

  • L. C. Rovati

  • I. Setnikar

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