Efficacy and Safety of Adjuvant Proton Therapy Combined with Surgery for Chondrosarcoma of the Skull Base: A Retrospective, Population-Based Study

  • L. F
  • S. B
  • V. C
 et al. 
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Purpose Chondrosarcoma is a rare malignant tumor of the cartilage affecting young adults. Surgery, followed by charged-particle irradiation, is considered the reference standard for the treatment of patients with grade I to II skull base chondrosarcoma. The present study was conducted to assess the effect of the quality of surgery and radiation therapy parameters on local control (LC) and overall survival (OS). Methods and Materials From 1996 to 2013, 159 patients (median age 40 years, range 12-83) were treated with either protons alone or a combination of protons and photons. The median total dose delivered was 70.2 Gy (relative biologic effectiveness [RBE]; range 67-71). Debulking and biopsy were performed in 133 and 13 patients, respectively. Results With a median follow-up of 77 months (range 2-214), 5 tumors relapsed based on the initial gross tumor volume. The 5- and 10-year LC rates were 96.4% and 93.5%, respectively, and the 5- and 10-year OS rates were 94.9% and 87%, respectively. A total of 16 patients died (13 of intercurrent disease, 3 of disease progression). On multivariate analysis, age

Author-supplied keywords

  • adolescent
  • adult
  • aged
  • alopecia
  • amnesia
  • article
  • asthenia
  • brain necrosis
  • cancer adjuvant therapy
  • cancer control
  • cancer prognosis
  • cancer recurrence
  • cancer surgery
  • cancer survival
  • child
  • chondrosarcoma
  • controlled study
  • dopamine receptor stimulating agent
  • drug resistant epilepsy
  • erythema
  • female
  • follow up
  • hearing disorder
  • hormone substitution
  • hospitalization
  • human
  • human tissue
  • hyperprolactinemia
  • hypofractionated radiotherapy
  • immunohistochemistry
  • intermethod comparison
  • major clinical study
  • male
  • mild erythema
  • nausea
  • nuclear magnetic resonance spectroscopy
  • occasional nausea
  • organs at risk
  • overall survival
  • patient safety
  • photon therapy
  • priority journal
  • progression free survival
  • proton therapy
  • radiation injury
  • radiation necrosis
  • retrospective study
  • secretory otitis media
  • serous otitis media
  • skull base tumor
  • temporal lobe necrosis
  • temporary focal alopecia
  • therapy effect
  • trigeminal nerve injury
  • tumor biopsy
  • tumor bleeding
  • unilateral hearing injury
  • unilateral hearing loss
  • unilateral serous otitis
  • visual field defect

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  • Feuvret L.

  • Bracci S.

  • Calugaru V.

  • Bolle S.

  • Mammar H.

  • De Marzi L.

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