Efficacy and safety of zotepine for the treatment of Taiwanese schizophrenic patients: A double-blind comparison with haloperidol

  • Hwang T
  • Lin S
  • Lin H
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Abstract

Background and Purpose: Zotepine is claimed to be a neuroleptic drug
with atypical features. However, there have been few double-blind
studies in Asian patients. The purpose of this study was to compare the
efficacy and safety of zotepine and haloperidol in Taiwanese patients
with schizophrenia.
Patients and Methods: Patients with positive symptoms (n = 70) were
enrolled into this double-blind, randomized study. Each patient received
either zotepine 150 mg/day or haloperidol 9 mg/day. The Positive and
Negative Syndrome Scale (PANSS), Brief Psychiatric Rating Scale (BPRS),
and Clinical Global Impression (CGI) were assessed on Days 0, 3, 7, 14,
28, and 42 after the start of treatment. Adverse events were recorded
during the trial period. The analyses were carried out on an
intent-to-treat basis with the last observation carried forward.
Results: In terms of the score reduction in the PANSS, BPRS, and CGI,
all analyses indicated that there were no significant differences
between the groups at the end of the trial. Patients who received
zotepine had no acute dystonia and less severe parkinsonism (p < 0.05 or
0.10), but significantly more dizziness, body weight gain, and pulse
rate increase.
Conclusion: In this 6-week trial, zotepine at 150 mg/day was as
efficacious as haloperidol 9 mg/day in the treatment of Taiwanese
patients with schizophrenia. Zotepine treatment produced fewer
extrapyramidal symptoms but had a greater frequency of sedative effects
compared to haloperidol.

Author-supplied keywords

  • zotepine; haloperidol; schizophrenia; double blind

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  • PMID: 11802520
  • SCOPUS: 2-s2.0-0035693497
  • SGR: 0035693497
  • ISBN: 0929-6646
  • PUI: 34071802
  • ISSN: 0929-6646

Authors

  • T J Hwang

  • S K Lin

  • H N Lin

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