Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo

  • Lipipun V
  • Kurokawa M
  • Suttisri R
 et al. 
  • 51


    Mendeley users who have this article in their library.
  • 81


    Citations of this article.


Twenty Thai medicinal plant extracts were evaluated for anti-herpes simplex virus type 1 (HSV-1) activity. Eleven of them inhibited plaque formation of HSV-1 more than 50% at 100μg/ml in a plaque reduction assay. Aglaia odorata, Moringa oleifera, and Ventilago denticulata among the 11 were also effective against thymidine kinase-deficient HSV-1 and phosphonoacetate- resistant HSV-1 strains. These therapeutic efficacies were characterized using a cutaneous HSV-1 infection in mice. The extract of M. oleifera at a dose of 750mg/kg per day significantly delayed the development of skin lesions, prolonged the mean survival times and reduced the mortality of HSV-1 infected mice as compared with 2% DMSO in distilled water (P

Author-supplied keywords

  • Antiviral agent
  • Herpes simplex virus
  • Thai medicinal plant
  • Therapeutic efficacy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free