Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo

  • Lipipun V
  • Kurokawa M
  • Suttisri R
 et al. 
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Abstract

Twenty Thai medicinal plant extracts were evaluated for anti-herpes simplex virus type 1 (HSV-1) activity. Eleven of them inhibited plaque formation of HSV-1 more than 50% at 100μg/ml in a plaque reduction assay. Aglaia odorata, Moringa oleifera, and Ventilago denticulata among the 11 were also effective against thymidine kinase-deficient HSV-1 and phosphonoacetate- resistant HSV-1 strains. These therapeutic efficacies were characterized using a cutaneous HSV-1 infection in mice. The extract of M. oleifera at a dose of 750mg/kg per day significantly delayed the development of skin lesions, prolonged the mean survival times and reduced the mortality of HSV-1 infected mice as compared with 2% DMSO in distilled water (P

Author-supplied keywords

  • Antiviral agent
  • Herpes simplex virus
  • Thai medicinal plant
  • Therapeutic efficacy

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