Efficacy and tolerability of pregabalin as preventive treatment for migraine: A 3-month follow-up study

  • Pizzolato R
  • Villani V
  • Prosperini L
 et al. 
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Migraine is a common neurological disorder and epidemiological studies have documented its high social and economic impact. Unfortunately, preventive treatment is often insufficient to substantially reduce migraine frequency or it is not well tolerated. Antiepileptic drugs are increasingly used in migraine prevention. However, data on efficacy and tolerability of pregabalin in patients with migraine are still lacking. Our aim was to evaluate efficacy and tolerability of pregabalin in patients with migraine. We recruited 47 patients who started pregabalin at 75 mg/day, which was titrated to 300 mg/day as tolerated. A total of six patients (13%) reported one or more side effects during the intake of pregabalin; however, three of them discontinued pregabalin, because side effects were intolerable and persistent. Statistically significant reduction in migraine frequency compared to baseline (p 

Author-supplied keywords

  • Disability
  • Migraine
  • Pregabalin
  • Prophylaxis therapy

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  • Raffaella Pizzolato

  • Veronica Villani

  • Luca Prosperini

  • Alessandro Ciuffoli

  • Giuliano Sette

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