Electrocardiographic and troponin T changes in acute ischaemic stroke

  • Fure B
  • Bruun W
  • Thommessen B
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BACKGROUND: The mechanisms explaining morphological electrocardiogram (ECG) changes and increased troponin T (TnT) in acute stroke are unclear. The aims of the present study were to assess the prevalence of ECG and TnT changes in acute ischaemic stroke, to investigate whether ischaemic-like ECG changes correlate to a rise in TnT and to examine whether ECG changes and elevated TnT predict a poor short-time outcome. METHODS: From 2000 to 2002 a total of 279 patients suffering from acute ischaemic stroke were included prospectively in the present study. ECG was carried out at admission and on day 1 in all patients. TnT was analysed at admission and on day 1. RESULTS: The most frequent ECG changes were: prolonged QTc 36.0%, ST depression 24.5%, atrial fibrillation 19.9% and T wave inversion 17.8%. In logistic regression analyses, ST depression and Q waves were significantly associated with a rise in TnT. TnT was elevated (>0.04 microg L(-1)) in 26 patients (9.6%). In logistic regression analyses, a rise in TnT was significantly associated with a poor short-term outcome (modified Rankin scale >3). CONCLUSION: ECG changes are prevalent in acute ischaemic stroke. ST depression and Q waves are related to an increase in TnT, suggesting that these ECG changes may indicate coexisting ischaemic heart disease. A rise in TnT predicts a poor outcome. Patients with acute ischaemic stroke should be offered adequate treatment with secondary prevention and preferably a follow-up with focus on cardiologic as well as neurological aspects

Author-supplied keywords

  • 80 and over
  • Acute Disease
  • Adult
  • Aged
  • Arrhythmias
  • Atrial Fibrillation
  • Biological Markers
  • Cardiac
  • Depression
  • Disease
  • Electrocardiography
  • Female
  • Heart
  • Humans
  • Long QT Syndrome
  • Male
  • Middle Aged
  • Norway
  • Prevalence
  • Prognosis
  • Prospective Studies
  • Stroke
  • Troponin
  • Troponin T
  • blood
  • complications
  • methods
  • physiopathology
  • secondary

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  • PMID: 16704560


  • B Fure

  • Wyller T Bruun

  • B Thommessen

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