Electrodiffusion model simulation of ionic channels: 1D simulations

  • Gardner C
  • Nonner W
  • Eisenberg R
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Abstract

The drift-diffusion (Poisson-Nernst-Planck) model is applied to ionic channels in biological membranes plus surrounding solution baths. Simulations of the K channel in KCl solutions using the TRBDF2 method are presented which show significant boundary layers at the ends of the channel. The computed current-voltage curve for the K channel shows excellent agreement with experimental measurements.

Author-supplied keywords

  • Biological channels
  • Diffusion models
  • Ion transport

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Authors

  • Carl L. Gardner

  • Wolfgang Nonner

  • Robert S. Eisenberg

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