Electrospun nanofibers of polyCD/PMAA polymers and their potential application as drug delivery system

  • Oliveira M
  • Suarez D
  • Rocha J
 et al. 
  • 21

    Readers

    Mendeley users who have this article in their library.
  • 13

    Citations

    Citations of this article.

Abstract

Abstract Herein, we used an electrospinning process to develop highly efficacious and hydrophobic coaxial nanofibers based on poly-cyclodextrin (polyCD) associated with poly(methacrylic acid) (PMAA) that combines polymeric and supramolecular features for modulating the release of the hydrophilic drug, propranolol hydrochloride (PROP). For this purpose, polyCD was synthesized and characterized, and its biocompatibility was assessed using fibroblast cytotoxicity tests. Moreover, the interactions between the guest PROP molecule and both polyCD and βCD were found to be spontaneous. Subsequently, PROP was encapsulated in uniaxial and coaxial polyCD/PMAA nanofibers. A lower PROP burst effect (reduction of approximately 50%) and higher modulation were observed from the coaxial than from the uniaxial fibers. Thus, the coaxial nanofibers could potentially be a useful strategy for developing a controlled release system for hydrophilic molecules.

Author-supplied keywords

  • Drug delivery system
  • Electrospinning
  • Poly-cyclodextrin
  • Polymeric nanofibers
  • Propranolol

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Michele F. Oliveira

  • Diego Suarez

  • Júlio Cézar Barbosa Rocha

  • Alvaro Vianna Novaes De Carvalho Teixeira

  • Maria E. Cortés

  • Frederico B. De Sousa

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free