Elements of a paracrine tubular renin-angiotensin system along the entire nephron

  • Rohrwasser A
  • Morgan T
  • Dillon H
 et al. 
  • 19

    Readers

    Mendeley users who have this article in their library.
  • 223

    Citations

    Citations of this article.

Abstract

The renin-angiotensin system is a major regulator of body sodium, predominantly through the actions of intrarenal angiotensin II of unclear origin. We show that polarized epithelium of the proximal tubule synthesizes and secretes angiotensinogen at its apical side and that the protein can be detected in urine as a function of dietary sodium. Furthermore, we demonstrate that renin is expressed and secreted in a restricted nephron segment, the connecting tubule, also in a sodium-dependent fashion. A paracrine renin-angiotensin system operating along the entire nephron may contribute to long-term arterial pressure regulation by integrating distant tubular sodium-reabsorbing functions.

Author-supplied keywords

  • Angiotensinogen
  • Kidney
  • Renin
  • Renin-angiotensin system
  • Sodium, dietary

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Andreas Rohrwasser

  • Terry Morgan

  • Harrison F. Dillon

  • Ling Zhao

  • Christopher W. Callaway

  • Elaine Hillas

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free