Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis

  • Bartoš A
  • Fialová L
  • Soukupová J
 et al. 
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Abstract

Neurofilaments are cytoskeletal proteins localized within axons, which may interact with the immune system during and following tissue destruction in multiple sclerosis (MS). Antibodies against the medium neurofilament subunit synthesized intrathecally may reflect axonal damage in MS patients. Both immunoglobulin G (IgG) and M (IgM) responses against the purified native medium subunit of neurofilaments (NFM) using enzyme-linked immunosorbent assay (ELISA) were determined in paired serum and cerebrospinal fluid samples obtained from 49 MS patients, 16 normal controls (CN), 21 control patients with miscellaneous diseases (CD) and 14 patients with neurodegenerative disorders (CDEG). Intrathecal production of IgM and IgG antibodies to NFM were elevated in MS patients compared with the CN or CD groups (p

Author-supplied keywords

  • Antibody
  • Cerebrospinal fluid
  • Intrathecal synthesis
  • Multiple sclerosis
  • Neurofilament

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