Emergence of Cytomegalovirus Disease in Patients Receiving Temozolomide: Report of Two Cases and Literature Review

  • Meije Y
  • Lizasoain M
  • García-Reyne A
 et al. 
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Temozolomide chemotherapy has become part of the therapy used to treat glioblastoma multiforme and refractory ana-plastic astrocytoma. Temozolomide frequently produces pro-found lymphopenia. We report 2 cases of cytomegalovirus disease that occurred in patients receiving temozolomide therapy and review 4 additional cases reported in the liter-ature. Narrow monitoring with cytomegalovirus antigenemia assay should be considered for recommendation. Temozolomide is an oral alkylating agent with antitumor ac-tivity that has been approved by the Food and Drug Admin-istration for newly diagnosed glioblastoma multiforme and re-fractory anaplastic astrocytoma [1, 2]. The use of temozolomide together with radiotherapy after surgical resection, followed by temozolomide monotherapy, resulted in a statistically signifi-cant survival benefit for up to 5 years of follow-up, compared with the use of only radiotherapy for the treatment of glio-blastoma after surgical resection [3, 4]. Postoperative adjuvant radiation therapy and temozolomide chemotherapy have be-come the standard treatment for these malignant diseases. Sev-eral trials investigating different future uses of temozolomide are currently being performed by the European Organization for Research and Treatment of Cancer and other groups. These temozolomide uses include the treatment of metastatic mela-noma, brain metastasis, and low-grade glioma. Temozolomide produces myelotoxic effects [5] and

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  • Yolanda Meije

  • Manuel Lizasoain

  • Ana García-Reyne

  • Pilar Martínez

  • Virginia Rodríguez

  • Francisco Ló Pez-Medrano

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