Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing

  • Shi R
  • Zhang J
  • Li C
 et al. 
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Abstract

A high rate of double point mutations in gyrA (56% of 87 ofloxacin-resistant Mycobacterium tuberculosis clinical isolates) indicates the emergence of fluoroquinolone resistance. This is the first report to describe denaturing high-pressure liquid chromatography analysis of mutations in gyrA of M. tuberculosis in a large number of clinical isolates.

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Authors

  • Ruiru Shi

  • Jianyuan Zhang

  • Chuanyou Li

  • Yuko Kazumi

  • Isamu Sugawara

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